Generic Name: hydrochlorothiazide and moexipril (hye droe klor oh THY a zide and moe EX a pril)
Brand Names: Uniretic
What is hydrochlorothiazide and moexipril?
Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Moexipril is in a group of drugs called ACE inhibitors. ACE stands for angiotensin converting enzyme. Moexipril lowers blood pressure and also relieves symptoms of fluid retention.
The combination of hydrochlorothiazide and moexipril is used to treat hypertension (high blood pressure).
Hydrochlorothiazide and moexipril may also be used for purposes not listed in this medication guide.
What is the most important information I should know about hydrochlorothiazide and moexipril?
Do not use this medication if you are unable to urinate.
You should not use this medication if you are allergic to any other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), ramipril (Altace), or trandolapril (Mavik).
Before taking hydrochlorothiazide and moexipril, tell your doctor if you have kidney disease (or are on dialysis), liver disease, glaucoma, congestive heart failure, gout, lupus, diabetes, or an allergy to sulfa drugs or penicillin.
Moexipril can cause birth defects in the baby if you take the medication during pregnancy. Do not use hydrochlorothiazide and moexipril without telling your doctor if you are pregnant or planning a pregnancy. Avoid the regular use of salt substitutes in your diet, and do not take potassium supplements while taking hydrochlorothiazide and moexipril, unless your doctor has told you to.
Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and moexipril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.
What should I discuss with my healthcare provider before taking hydrochlorothiazide and moexipril?
Do not use this medication if you are allergic to hydrochlorothiazide or moexipril, or if you are unable to urinate.
You should not use this medication if you are allergic to other ACE inhibitor, such as benazepril (Lotensin), captopril (Capoten), fosinopril (Monopril), enalapril (Vasotec), lisinopril (Prinivil, Zestril), moexipril (Univasc), perindopril (Aceon), ramipril (Altace), or trandolapril (Mavik).
To make sure you can safely take hydrochlorothiazide and moexipril, tell your doctor if you have any of these other conditions:
- kidney disease (or if you are on dialysis);
- liver disease;
glaucoma;
congestive heart failure;
gout;
lupus;
diabetes; or
an allergy to sulfa drugs or penicillin.
FDA pregnancy category D. Do not use this medication if you are pregnant. Stop using this medication and tell your doctor right away if you become pregnant. Moexipril can cause birth defects. Use effective birth control while taking hydrochlorothiazide and moexipril. Hydrochlorothiazide can pass into breast milk and may harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby.
How should I take hydrochlorothiazide and moexipril?
Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label.
Your doctor may occasionally change your dose to make sure you get the best results.
Take each dose with a full glass of water.
Conditions that may cause very low blood pressure include: vomiting, diarrhea, heavy sweating, heart disease, dialysis, a low-salt diet, or taking diuretics (water pills). Follow your doctor's instructions about the type and amount of liquids you should drink while taking hydrochlorothiazide and moexipril. Tell your doctor if you have a prolonged illness that causes diarrhea or vomiting.
Your blood pressure will need to be checked often. Visit your doctor regularly.
Your blood and urine may also be tested if you have been vomiting or are dehydrated.
Hydrochlorothiazide can interfere with the results of a thyroid test. Tell any doctor who treats you that you are using a thiazide diuretic.
Keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Store at room temperature away from moisture, heat, and light.
See also: Hydrochlorothiazide and moexipril dosage (in more detail)
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include nausea, weakness, dizziness, dry mouth, thirst, muscle pain or weakness, or feeling like you might pass out.
What should I avoid while taking hydrochlorothiazide and moexipril?
Avoid becoming overheated or dehydrated during exercise and in hot weather. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall. Drinking alcohol can increase certain side effects of hydrochlorothiazide and moexipril.
Do not use potassium supplements or salt substitutes while you are taking hydrochlorothiazide and moexipril, unless your doctor has told you to.
Hydrochlorothiazide and moexipril side effects
Get emergency medical help if you have any of these signs of an allergic reaction: hives; severe stomach pain; difficulty breathing; swelling of your face, lips, tongue, or throat. Call your doctor at once if you have a serious side effect such as:
eye pain, vision problems;
high potassium (slow heart rate, weak pulse, muscle weakness, tingly feeling);
low potassium (confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, muscle weakness or limp feeling);
dry mouth, thirst, nausea, vomiting;
feeling weak, drowsy, restless, or light-headed;
a red, blistering, peeling skin rash;
jaundice (yellowing of the skin or eyes);
urinating less than usual or not at all;
swelling, weight gain, feeling short of breath; or
fever, chills, body aches, flu symptoms.
Less serious side effects may include:
cough;
dizziness, headache, tired feeling;
muscle or back pain;
runny nose;
sleep problems (insomnia);
diarrhea, constipation, upset stomach; or
mild skin rash, increased sweating.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Hydrochlorothiazide and moexipril Dosing Information
Usual Adult Dose for Hypertension:
Initial dose: 1 tablet (12.5 mg-7.5 mg) orally once a day.
Maintenance dose: Up to 25 mg-15 mg orally once a day.
What other drugs will affect hydrochlorothiazide and moexipril?
Cold or allergy medicine, sedatives, narcotic pain medicine, sleeping pills, muscle relaxers, and medicine for seizures, depression or anxiety can add to some of the side effects of hydrochlorothiazide and moexipril. Tell your doctor if you regularly use any of these medicines.
Tell your doctor about all other medicines you use, especially:
other diuretics (water pills) or blood pressure medications;
gold injections to treat arthritis;
lithium (Lithobid, Eskalith);
a tetracycline antibiotic such as demeclocycline (Declomycin), doxycycline (Adoxa, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn, Vectrin), or tetracycline (Brodspec, Panmycin, Sumycin, Tetracap);
digoxin (Lanoxin);
cholestyramine (Prevalite, Questran) or colestipol (Colestid);
steroids (prednisone and others);
a tetracycline antibiotic such as demeclocycline (Declomycin), doxycycline (Adoxa, Alodox, Avidoxy, Oraxyl, Doryx, Oracea, Vibramycin), minocycline (Dynacin, Minocin, Solodyn), or tetracycline (Ala-Tet, Brodspec, Panmycin, Sumycin, Tetracap);
NSAIDs (non-steroidal anti-inflammatory drugs) such as aspirin, ibuprofen (Motrin, Advil), diclofenac (Voltaren), indomethacin, naproxen (Aleve, Naprosyn), piroxicam (Feldene), nabumetone (Relafen), etodolac (Lodine), and others; or
insulin or oral diabetes medication.
This list is not complete and other drugs may interact with hydrochlorothiazide and moexipril. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.
More hydrochlorothiazide and moexipril resources
- Hydrochlorothiazide and moexipril Side Effects (in more detail)
- Hydrochlorothiazide and moexipril Dosage
- Hydrochlorothiazide and moexipril Use in Pregnancy & Breastfeeding
- Drug Images
- Hydrochlorothiazide and moexipril Drug Interactions
- Hydrochlorothiazide and moexipril Support Group
- 1 Review for Hydrochlorothiazide and moexipril - Add your own review/rating
Compare hydrochlorothiazide and moexipril with other medications
- High Blood Pressure
Where can I get more information?
- Your pharmacist can provide more information about hydrochlorothiazide and moexipril.
See also: hydrochlorothiazide and moexipril side effects (in more detail)
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